We have added rat efferent duct ligation expression profile data to the database.
We are pleased to announce that we have added the transcriptional profiling data of the rat epididymis after efferent duct ligation from the paper Differential Gene Expression among the Proximal Segments of the Rat Epididymis Is Lost after Efferent Duct Ligation by Terry T. Turner and colleagues. From the abstract:
In the present study 15 day, unilateral efferent duct ligation (EDL) was used to deprive ipsilateral rat epididymes of lumicrine regulation. Segments 1-4 of EDL epididymes and contralateral, sham-operated tissues were collected individually. Microarray analysis of gene expression was used to determine the effect of lumicrine factor deprivation on the transcriptome-wide gene expression of each segment studied. Over 11,000 genes were detected as being expressed in each of the 4 segments examined. Over 2,000 genes responded significantly to EDL in segment 1, a numberthat declined in each succeeding segment. In the absence of lumicrine factors, the 4 segments regressed to a transcriptionally undifferentiated state, which was consistent with a less differentiated histology also seen after EDL. Interestingly, deprivation of lumicrine factors could stimulate an individuals gene's expressionin some segments yet suppress it in others. Such results revela a higher complexity to the regulation of rat epididymal segments than heretofore appreciated.
These data can be queried for the examination of segmental expression profiles of individual genes or families of genes. These data complement the profiling data from the mouse and rat epididymis provided by Wyeth Research and Dr. Terry Turner of the University of Virginia School of Medicine, which are already present in the MRG. We hope that this new resource will assist interested investigators in developing new hypotheses regarding the cellular and molecular biology of the epididymis and provide new insights into epididymal function.

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